LOCAL OSRS REFERENCE

Sanfew serum

Source revision 15236706 · Saved 2026-09-27 · Sources & credits

On this page
1 dose2 dose3 dose4 dose
Sanfew serum(1)
Released13 March 2007 (Update)
MembersYes
Quest itemNo
Properties
TradeableYes
EquipableNo
StackableNo
NoteableYes
OptionsDrink, Empty, Drop
ExamineA 1 dose Sanfew Serum.
Values
Value120 coins
High alch72 coins
Low alch48 coins
Weight0.02 kg
Grand Exchange
Exchange4,448 coins (info)
Buy limit2,000
Daily volume399
View real-time prices
Advanced data
Item ID10931
LinkMOID

Sanfew serum is a potion invented by the druid Sanfew that combines the properties of the super restore, superantipoison, and Relicym's balm. It restores 4 + 30% of the player's base level (rounded down) per dose in all skills except Hitpoints, provides 6 minutes of immunity to poison, and provides 15 minutes of immunity to disease.

Sanfew serums can also be used on nail beasts, which can deal 20-40 damage per dose and grants melee experience. This requires the player to have no weapons equipped; if they do, it will automatically be unequipped if there is space in their inventory.

Sanfew serum is made by adding, in order, unicorn horn dust, clean snake weed, and nail beast nails to an already made super restore. Partially completed Sanfew serums are called mixture - step 1 and step 2, but are not drinkable in these forms. Level 65 Herblore and completion of Zogre Flesh Eaters is required in order to make this potion.

96 Herblore experience is given for a completed 1-dose Sanfew serum, 128 experience for a 2-dose serum, 160 experience for a 3-dose serum, and 192 experience for a 4-dose serum. Or more simply, the total experience given can be calculated with: Experience=32×Doses+64

As Sanfew serums' higher price often makes super restores and prayer potions more cost efficient for restoring prayer, Sanfew serums are notably useful in situations where prayer restoration as well as poison protection are needed and inventory space is limited, such as Dagannoth Kings, as it fulfills the two requirements in one inventory space. Similarly, Sanfew serums are effective for fighting The Nightmare as they offer the same utility against parasites as Relicym's balm while also offering prayer restoration.

Effects

Stat/Prayer restore is calculated with: ⌊SkillLevel×310⌋+4

Skills / Prayer Level Boost Skills / Prayer Level Boost Skills / Prayer Level Boost
1-3 +4 34-36 +14 67-69 +24
4-6 +5 37-39 +15 70-73 +25
7-9 +6 40-43 +16 74-76 +26
10-13 +7 44-46 +17 77-79 +27
14-16 +8 47-49 +18 80-83 +28
17-19 +9 50-53 +19 84-86 +29
20-23 +10 54-56 +20 87-89 +30
24-26 +11 57-59 +21 90-93 +31
27-29 +12 60-63 +22 94-96 +32
30-33 +13 64-66 +23 97-99 +33

If a ring of the gods (i) or Prayer cape is equipped, or alternatively if a Prayer cape or holy wrench is in the player's inventory, the amount of restored Prayer points is calculated with: ⌊PrayerLevel×32100⌋+4

This does not affect the rate of restoration of stats other than Prayer.

Prayer Level Boost Prayer Level Boost Prayer Level Boost
1-3 +4 35-37 +15 69-71 +26
4-6 +5 38-40 +16 72-74 +27
7-9 +6 41-43 +17 75-78 +28
10-12 +7 44-46 +18 79-81 +29
13-15 +8 47-49 +19 82-84 +30
16-18 +9 50-53 +20 85-87 +31
19-21 +10 54-56 +21 88-90 +32
22-24 +11 57-59 +22 91-93 +33
25-28 +12 60-62 +23 94-96 +34
29-31 +13 63-65 +24 97-99 +35
32-34 +14 66-68 +25

Creation

The full creation process requires an untradeable ingredient, Snake weed, which can only be found by searching marshy jungle vines south-west of Tai Bwo Wannai or as a drop from Jogres and Tribesmen. Each step of the process must be done manually and one at a time, there is no make-x menu. The prescription goggles will save a secondary ingredient, but the reagent pouch will not hold them.

Requirements
SkillLevelXP
Herblore Herblore65 (b)28.5
Quest points Partial completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Super restore(1)12,487
Unicorn horn dust1672
Total cost3,159
Mixture - step 1(1)1N/A
Requirements
SkillLevelXP
Herblore Herblore65 (b)38
Quest points Partial completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Super restore(2)14,855
Unicorn horn dust1672
Total cost5,527
Mixture - step 1(2)1N/A
Requirements
SkillLevelXP
Herblore Herblore65 (b)47.5
Quest points Partial completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Super restore(3)17,286
Unicorn horn dust1672
Total cost7,958
Mixture - step 1(3)1N/A
Requirements
SkillLevelXP
Herblore Herblore65 (b)57
Quest points Partial completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Super restore(4)110,012
Unicorn horn dust1672
Total cost10,684
Mixture - step 1(4)1N/A

Requirements
SkillLevelXP
Herblore Herblore65 (b)31.5
Quest points Partial completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Mixture - step 1(1)1N/A
Snake weed1N/A
Total cost0
Mixture - step 2(1)1N/A
Requirements
SkillLevelXP
Herblore Herblore65 (b)42
Quest points Partial completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Mixture - step 1(2)1N/A
Snake weed1N/A
Total cost0
Mixture - step 2(2)1N/A
Requirements
SkillLevelXP
Herblore Herblore65 (b)52.5
Quest points Partial completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Mixture - step 1(3)1N/A
Snake weed1N/A
Total cost0
Mixture - step 2(3)1N/A
Requirements
SkillLevelXP
Herblore Herblore65 (b)63
Quest points Partial completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Mixture - step 1(4)1N/A
Snake weed1N/A
Total cost0
Mixture - step 2(4)1N/A

Requirements
SkillLevelXP
Herblore Herblore65 (b)36
Quest points Completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Mixture - step 2(1)1N/A
Nail beast nails1739
Total cost739
Sanfew serum(1)14,448
Profit3,709
Profit after GE Tax3,621
Requirements
SkillLevelXP
Herblore Herblore65 (b)48
Quest points Completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Mixture - step 2(2)1N/A
Nail beast nails1739
Total cost739
Sanfew serum(2)19,200
Profit8,461
Profit after GE Tax8,277
Requirements
SkillLevelXP
Herblore Herblore65 (b)60
Quest points Completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Mixture - step 2(3)1N/A
Nail beast nails1739
Total cost739
Sanfew serum(3)113,689
Profit12,950
Profit after GE Tax12,677
Requirements
SkillLevelXP
Herblore Herblore65 (b)72
Quest points Completion of Zogre Flesh Eaters
Members
Ticks2 (1.2s)
Materials
ItemQuantityCost
Mixture - step 2(4)1N/A
Nail beast nails1739
Total cost739
Sanfew serum(4)119,963
Profit19,224
Profit after GE Tax18,825

Requirements
SkillLevelXP
Herblore Herblore65 (b)96
Quest points Completion of Zogre Flesh Eaters
Members
TicksN/A
Materials
ItemQuantityCost
Super restore(1)12,487
Unicorn horn dust1672
Snake weed1N/A
Nail beast nails1739
Total cost3,898
Sanfew serum(1)14,448
Profit550
Profit after GE Tax462
Requirements
SkillLevelXP
Herblore Herblore65 (b)128
Quest points Completion of Zogre Flesh Eaters
Members
TicksN/A
Materials
ItemQuantityCost
Super restore(2)14,855
Unicorn horn dust1672
Snake weed1N/A
Nail beast nails1739
Total cost6,266
Sanfew serum(2)19,200
Profit2,934
Profit after GE Tax2,750
Requirements
SkillLevelXP
Herblore Herblore65 (b)160
Quest points Completion of Zogre Flesh Eaters
Members
TicksN/A
Materials
ItemQuantityCost
Super restore(3)17,286
Unicorn horn dust1672
Snake weed1N/A
Nail beast nails1739
Total cost8,697
Sanfew serum(3)113,689
Profit4,992
Profit after GE Tax4,719
Requirements
SkillLevelXP
Herblore Herblore65 (b)192
Quest points Completion of Zogre Flesh Eaters
Members
TicksN/A
Materials
ItemQuantityCost
Super restore(4)110,012
Unicorn horn dust1672
Snake weed1N/A
Nail beast nails1739
Total cost11,423
Sanfew serum(4)119,963
Profit8,540
Profit after GE Tax8,141

Price per dose

Item GE price
per potion
GE price
per dose
GE volume
Sanfew serum(1) 4,448 4,448 399
Sanfew serum(2) 9,200 4,600 358
Sanfew serum(3) 13,689 4,563 1,944
Sanfew serum(4) 19,963 4,991 90,316

Item sources

Sanfew serum(3)

SourceLevelQuantityRarity
The Nightmare814 1–85/100
Phosani's Nightmare1024 6–125/100

Shop locations

SellerLocationNumber
in stock
Restock
time
Price
sold at
Price
bought at
Change
Per
Members
~ Uglug's stuffsies ~Jiggig01m 240 1442.0%Members

Sanfew serum(4)

SourceLevelQuantityRarity
Kraken291 24/128
Vet'ion454 20 (noted)5/126
Thermonuclear smoke devil301 23/107
Coffin (Hallowed Sepulchre) High66 1–21/10
Grand Hallowed Coffin84 1–21/10
Hallowed sackN/A 1–22 × 1/10
Calvar'ion264 6 (noted)5/128

Changes

Date Changes
19 May 2016
(Update)

Sanfew serum can now be shared with the share potion spell.

15 April 2016
(Update)

Half full potions could now be turned into bank placeholders.

7 April 2016
(Update)

Drinking any kind of antipoison will no longer decrease your poison immunity.

1 May 2014
(Update)

Sanfew serum is now correctly considered a potion rather than food when applying consumption delays and within the Duel Arena.

Sources & credits

“Sanfew serum” by Old School RuneScape Wiki contributors, revision 15236706. Text adapted under CC BY-NC-SA 3.0; adapted text is shared under the same license. Formatting and navigation changed; Wiki scripts and editing controls omitted. Game imagery © Jagex Ltd. Imported image-file descriptions retain their own credits and licensing statements.

Original source address: https://oldschool.runescape.wiki/w/Sanfew_serum?oldid=15236706

This saved page may differ from the current game. Interactive Wiki tools are not reproduced.

About this library and media credits

Game icons © Jagex Ltd, via the OSRS Wiki. Interface icons by Lucide.