Rune may refer to:
- Runite, a type of metal made from runite ore
- Rune equipment, level 40 melee weapons and armour made from runite
- Runes, used to cast spells with the Magic skill
Rune essence, the raw material that players can turn into low-level runes via Runecraft
Pure essence, the raw material that members can turn into higher-level runes
- Rune-Draw, a game of chance similar to blackjack played against Robin during the Ghosts Ahoy quest.